Bone Abstracts

Infections within or in the vicinity of the skeleton induce osteolytic diseases such as periodontitis, septic arthritis, osteomyelitis. Although host production of osteotropic cytokines is crucial, the precise mechanism by which pathogen associated molecular patterns induce osteoclastogenesis and bone loss is not fully understood. Recognition of these molecules by pattern recognition receptors is highly preserved through evolution with trans-membrane Toll-like receptor (TLR) f...